How Do Q Fever Causing Bacteria Grow Inside Human Cells?

Grant number: 1062383 | Funding period: 2014 - 2016

Completed

Abstract

This study explores how the bacterium Coxiella burnetii causes the serious infectious disease Q fever. Coxiella is a potential biological weapon because it is very stable in the environment and few organisms are required to cause disease. Coxiella is able to commandeer human cells to replicate in a specialized vacuole but little is understood about how they do this. We will examine the virulence factors of Coxiella and investigate how they allow the bacteria to replicate inside human cells.

Related publications (8)

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A farnesylated Coxiella burnetii effector forms a multimeric complex at the mitochondrial outer membrane during infection

LF Fielden, JH Moffatt, Y Kang, MJ Baker, CA Khoo, CR Roy, D Stojanovski, HJ Newton

2017-05-01

Coxiella burnetii, the causative agent of Q fever, establishes a unique lysosome-derived intracellular niche termed the Coxiella-c..

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Targeting mitochondria: how intravacuolar bacterial pathogens manipulate mitochondria

LF Fielden, Y Kang, HJ Newton, D Stojanovski

2017-01-01

Manipulation of host cell function by bacterial pathogens is paramount for successful invasion and creation of a niche conducive t..

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The Effector Cig57 Hijacks FCHO-Mediated Vesicular Trafficking to Facilitate Intracellular Replication of Coxiella burnetii

EA Latomanski, P Newton, CA Khoo, HJ Newton

2016-12-21

Coxiella burnetii is an intracellular bacterial pathogen that infects alveolar macrophages and replicates within a unique lysosome..

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Applying Fluorescence Resonance Energy Transfer (FRET) to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing

Patrice Newton, Eleanor A Latomanski, Hayley J Newton

2016-07-01

Coxiella burnetii, the causative agent of Q fever, is an intracellular pathogen that relies on a Type IV Dot/Icm Secretion System ..

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Murine alveolar macrophages are highly susceptible to replication of Coxiella burnetii phase II In Vitro

TD Fernandes, LD Cunha, JM Ribeiro, LM Massis, DS Lima-Junior, HJ Newton, DS Zamboni

2016-01-01

Coxiella burnetii is a Gram-negative bacterium that causes Q fever in humans. Q fever is an atypical pneumonia transmitted through..

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Coxiella burnetii: Turning hostility into a home

JH Moffatt, P Newton, HJ Newton

2015-05-01

Coxiella burnetii, the causative agent of the human disease Q fever, is a unique intracellular bacterial pathogen. Coxiella replic..

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Post-modern pathogens: Surprising activities of translocated effectors from E. coli and Legionella

JS Pearson, Y Zhang, HJ Newton, EL Hartland

2015-02-01

Many bacterial pathogens have the ability to manipulate cellular processes and interfere with host cell function through the trans..

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Dot/Icm effector translocation by Legionella longbeachae creates a replicative vacuole similar to that of Legionella pneumophila despite translocation of distinct effector repertoires

RE Wood, P Newton, EA Latomanski, HJ Newton

2015-01-01

Legionella organisms are environmental bacteria and accidental human pathogens that can cause severe pneumonia, termed Legionnaire..

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